Baicalein inhibits IL-1ß-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes.
Toxicol Res
; 40(2): 237-246, 2024 Apr.
Article
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| MEDLINE
| ID: mdl-38525128
ABSTRACT
Baicalein is a flavonoid extracted from the roots of Scutellaria baicalensis and Scutellaria lateriflora. This compound exerts various biochemical activities, including antioxidant and anti-inflammatory effects. The study aimed to investigate the effect of baicalein on articular cartilage cells and elucidate its underlying mechanism. In primary rat chondrocyte cultures, treatment with baicalein demonstrated a reduction in the loss of proteoglycan and extracellular matrix degradation induced by interleukin (IL)-1ß. Baicalein suppressed IL-1ß-induced catabolic responses, including the expression and activation of matrix metalloproteinase (MMP)-13, MMP-3, and MMP-1. In addition, baicalein effectively reduced nitric oxide and prostaglandin E2 production, and it downregulated the expression of inducible nitric oxide synthase and cyclooxygenase-2 in primary rat chondrocytes. Furthermore, baicalein downregulated IL-1ß-induced inflammatory chemokines and cytokines, such as GM-CSF and MCP-1. These findings suggest that baicalein could potentially mitigate the catabolic responses of IL-1ß in chondrocytes, making it a promising candidate for both the prevention and treatment of osteoarthritis. Supplementary Information The online version contains supplementary material available at 10.1007/s43188-024-00225-4.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Toxicol Res
Año:
2024
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Article