Ketamine induces insomnia-like symptom of zebrafish at environmentally relevant concentrations by mediating GABAergic synapse.

Guo, Tingting; He, Yuhang; Mao, Shengqiang; Yang, Ying; Xie, Hongguan; Zhang, Sifan; Dai, Shuiping

Guo, Tingting; He, Yuhang; Mao, Shengqiang; Yang, Ying; Xie, Hongguan; Zhang, Sifan; Dai, Shuiping.

Afiliación

Guo T; Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
He Y; College of Ecology and Environment, Chengdu University of Technology, Chengdu, People's Republic of China.
Mao S; West China School of Public Health, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Yang Y; Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Xie H; Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Zhang S; College of Ecology and Environment, Chengdu University of Technology, Chengdu, People's Republic of China.
Dai S; Division of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

Environ Toxicol ; 39(7): 3897-3905, 2024 Jul.

Article en En | MEDLINE | ID: mdl-38567678

Asunto(s)

Ketamina; Trastornos del Inicio y del Mantenimiento del Sueño; Pez Cebra; Animales; Ketamina/toxicidad; Trastornos del Inicio y del Mantenimiento del Sueño/inducido químicamente; Contaminantes Químicos del Agua/toxicidad; Larva/efectos de los fármacos; Conducta Animal/efectos de los fármacos; Sinapsis/efectos de los fármacos; Receptores de GABA/genética; Receptores de GABA/metabolismo; Receptores de GABA/efectos de los fármacos; Simulación del Acoplamiento Molecular

Palabras clave

environmental risk; environmentally relevant concentration; insomnialike behaviors; ketamine; sleep health

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Trastornos del Inicio y del Mantenimiento del Sueño / Ketamina Límite: Animals Idioma: En Revista: Environ Toxicol Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2024 Tipo del documento: Article

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