Endoscopic ultrasound-guided biopsies vs surgical specimens for establishing patient-derived pancreatic cancer organoids: A systematic review and meta-analysis.
Gastrointest Endosc
; 2024 Apr 07.
Article
en En
| MEDLINE
| ID: mdl-38593932
ABSTRACT
BACKGROUND AND AIMS:
Patient-Derived Tumor Organoids (PDTOs) is a promising new disease model in pancreatic cancer for use in personalized medicine, but overall success rate (SR) of establishing these cultures from endoscopic ultrasound-guided biopsies is unknown.METHODS:
We searched relevant databases publications reporting SR of PDTO establishment from pancreatic cancer. The primary outcome was SR stratified on tissue acquisition method (EUS-guided biopsies, percutaneous biopsies, and surgical specimens).RESULTS:
We identified 24 studies including 1,053 attempts at establishing PDTOs. Overall SR was 63% (95% CI 54%-72%). Pooled SR of PDTO establishment from EUS-guided biopsies, percutaneous biopsies, and surgical specimens were 60% (95% CI 43-76%), 36% (95% CI 14-61%) and 62% (95% CI 48-75%), respectively and did not differ significantly (p = 0.1975).CONCLUSION:
The SR of PDTO establishment from EUS-guided biopsies is comparable to surgical specimens. Both techniques are suitable for tissue acquisition for PDTOs in clinical and research settings.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Gastrointest Endosc
Año:
2024
Tipo del documento:
Article