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Selective plasticity of layer 2/3 inputs onto distal forelimb controlling layer 5 corticospinal neurons with skilled grasp motor training.
Takashima, Yoshio; Biane, Jeremy S; Tuszynski, Mark H.
Afiliación
  • Takashima Y; Department of Neurosciences, UCSD, La Jolla, CA 92093, USA. Electronic address: yoshi.takashima@gmail.com.
  • Biane JS; Department of Psychiatry, UCSF, San Francisco, CA 94158, USA.
  • Tuszynski MH; Department of Neurosciences, UCSD, La Jolla, CA 92093, USA; Department of Psychiatry, UCSF, San Francisco, CA 94158, USA; VA Medical Center, San Diego, CA 92161, USA. Electronic address: mtuszynski@health.ucsd.edu.
Cell Rep ; 43(4): 113986, 2024 Apr 23.
Article en En | MEDLINE | ID: mdl-38598336
ABSTRACT
Layer 5 neurons of the neocortex receive their principal inputs from layer 2/3 neurons. We seek to identify the nature and extent of the plasticity of these projections with motor learning. Using optogenetic and viral intersectional tools to selectively stimulate distinct neuronal subsets in rat primary motor cortex, we simultaneously record from pairs of corticospinal neurons associated with distinct features of motor output control distal forelimb vs. proximal forelimb. Activation of Channelrhodopsin2-expressing layer 2/3 afferents onto layer 5 in untrained animals produces greater monosynaptic excitation of neurons controlling the proximal forelimb. Following skilled grasp training, layer 2/3 inputs onto corticospinal neurons controlling the distal forelimb associated with skilled grasping become significantly stronger. Moreover, peak excitatory response amplitude nearly doubles while latency shortens, and excitatory-to-inhibitory latencies become significantly prolonged. These findings demonstrate distinct, highly segregated, and cell-specific plasticity of layer 2/3 projections during skilled grasp motor learning.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miembro Anterior / Corteza Motora / Plasticidad Neuronal Límite: Animals Idioma: En Revista: Cell Rep Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miembro Anterior / Corteza Motora / Plasticidad Neuronal Límite: Animals Idioma: En Revista: Cell Rep Año: 2024 Tipo del documento: Article
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