The impact of baseline dietary fatty acid intake on the association between lipoprotein(a) and mortality in two US cohorts.
JRSM Cardiovasc Dis
; 13: 20480040241247394, 2024.
Article
en En
| MEDLINE
| ID: mdl-38606365
ABSTRACT
Background:
Lipoprotein(a) (Lp(a)) is an established casual risk factor for atherosclerotic cardiovascular disease. It remains unknown whether dietary fat modifies the association of Lp(a) with cardiovascular death.Aim:
To understand if dietary fat modifies the association between Lp(a) and cardiovascular death.Methods:
We utilized the Atherosclerotic Risk in Communities (ARIC) study and National Health and Nutrition Examination Survey (NHANES) III cohorts and used multivariate cox proportional hazard modeling to test the association between Lp(a), dietary fats, and cardiovascular death.Results:
The sample (n = 22,805) had average age 51.3 years and was mostly female (55.4%). Lp(a) ≥ 30â mg/dL was associated with CV death in both ARIC (1.36, p = 0.001) and NHANES (1.31, p = 0.03). In multivariate analysis, no categorical or individual fatty acids modified the association between Lp(a) and CV death.Conclusion:
There was no evidence that baseline dietary fat intake modified the association between Lp(a) and CV death.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
JRSM Cardiovasc Dis
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos