From Blur to Brilliance: The Ascendance of Advanced Microscopy in Neuronal Cell Biology.
Annu Rev Neurosci
; 47(1): 235-253, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38608643
ABSTRACT
The intricate network of the brain's neurons and synapses poses unparalleled challenges for research, distinct from other biological studies. This is particularly true when dissecting how neurons and their functional units work at a cell biological level. While traditional microscopy has been foundational, it was unable to reveal the deeper complexities of neural interactions. However, an imaging renaissance has transformed our capabilities. Advancements in light and electron microscopy, combined with correlative imaging, now achieve unprecedented resolutions, uncovering the most nuanced neural structures. Maximizing these tools requires more than just technical proficiency. It is crucial to align research aims, allocate resources wisely, and analyze data effectively. At the heart of this evolution is interdisciplinary collaboration, where various experts come together to translate detailed imagery into significant biological insights. This review navigates the latest developments in microscopy, underscoring both the promise of and prerequisites for bending this powerful tool set to understanding neuronal cell biology.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Microscopía
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Neurosci
Año:
2024
Tipo del documento:
Article