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Synthesis, in vitro and in silico anticancer evaluation of novel pyridin-2-yl estra-1,3,5(10)-triene derivatives.
Stevanovic, Milica Z; Bekic, Sofija S; Petri, Edward T; Celic, Andjelka S; Jakimov, Dimitar S; Sakac, Marija N; Kuzminac, Ivana Z.
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  • Stevanovic MZ; Department of Chemistry, Biochemistry & Environmental Protection, University of Novi Sad, Faculty of Sciences, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia.
  • Bekic SS; Department of Chemistry, Biochemistry & Environmental Protection, University of Novi Sad, Faculty of Sciences, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia.
  • Petri ET; Department of Biology & Ecology, University of Novi Sad, Faculty of Sciences, Trg Dositeja Obradovica 2, 21000 Novi Sad, Serbia.
  • Celic AS; Department of Biology & Ecology, University of Novi Sad, Faculty of Sciences, Trg Dositeja Obradovica 2, 21000 Novi Sad, Serbia.
  • Jakimov DS; Oncology Institute of Vojvodina, Faculty of Medicine, University of Novi Sad, Put Dr Goldmana 4, 21204 Sremska Kamenica, Serbia.
  • Sakac MN; Department of Chemistry, Biochemistry & Environmental Protection, University of Novi Sad, Faculty of Sciences, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia.
  • Kuzminac IZ; Department of Chemistry, Biochemistry & Environmental Protection, University of Novi Sad, Faculty of Sciences, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia.
Future Med Chem ; 16(11): 1127-1145, 2024.
Article en En | MEDLINE | ID: mdl-38629440
The series of pyridine-containing estra-1,3,5(10)-triene derivatives was synthesized. One novel derivative stood out by its excellent activity against the MDA-MB-231 cell line. This activity can be explained by its moderate inhibition of the AKR1C3 enzyme.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensayos de Selección de Medicamentos Antitumorales / Proliferación Celular / Simulación del Acoplamiento Molecular / Antineoplásicos Límite: Humans Idioma: En Revista: Future Med Chem Año: 2024 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensayos de Selección de Medicamentos Antitumorales / Proliferación Celular / Simulación del Acoplamiento Molecular / Antineoplásicos Límite: Humans Idioma: En Revista: Future Med Chem Año: 2024 Tipo del documento: Article