The impact of multimorbidity and functional limitation on quality of life in patients with heart failure: A multi-site study.
J Am Geriatr Soc
; 72(6): 1750-1759, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38634747
ABSTRACT
BACKGROUND:
Multimorbidity and functional limitation are associated with poor outcomes in heart failure (HF). However, the individual and combined effect of these on health-related quality of life in patients with HF is not well understood.METHODS:
Patients aged ≥30 years with two or more HF diagnostic codes and one or more HF-related prescription drugs from four U.S. institutions were mailed a survey to measure patient-centric factors including functional status (activities of daily living [ADLs]) and health-related quality of life (PROMIS-29 Health Profile). Patients with HF from January 1, 2013 to February 1, 2018 were included. Multimorbidity was defined as ≥2 non-cardiovascular comorbidities; functional limitation as any limitation in at least one of eight ADLs. Patients were categorized into four groups by multimorbidity (Yes/No) and functional limitation (Yes/No). We dichotomized the PROMIS-29 sub-scale scores at the median and calculated odd ratios for the four multimorbidity/functional limitation groups.RESULTS:
A total of 3330 patients with HF returned the survey (response rate 31%); 3020 completed the questions of interest and were retained. Among these patients (45% female; mean age 73 [standard deviation 12] years), 29% had neither multimorbidity nor functional limitation, 24% had multimorbidity only, 22% had functional limitation only, and 25% had both. After adjustment, having functional limitation only was associated with higher anxiety (odds ratio [OR] 3.44, 95% confidence interval [CI] 2.66-4.45), depression (OR 3.11, 95% CI 2.39-4.06), and fatigue (OR 4.19, 95% CI 3.25-5.40); worse sleep (OR 2.14, 95% CI 1.69-2.72) and pain (OR 6.73, 95% CI 5.15-8.78); and greater difficulty with social activities (OR 9.40, 95% CI 7.19-12.28) compared with having neither. Results were similar for having both multimorbidity and functional limitation.CONCLUSION:
Patients with only functional limitation have similar poor health-related quality of life scores as those with both multimorbidity and functional limitation, underscoring the important role that physical functioning plays in the well-being of patients with HF.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Calidad de Vida
/
Actividades Cotidianas
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Multimorbilidad
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Insuficiencia Cardíaca
Límite:
Aged
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Aged80
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Female
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Humans
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Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Am Geriatr Soc
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos