Age-specific prevalence of IgG against measles/rubella and the impact of routine and supplementary immunization activities: A multistage random cluster sampling study with mathematical modelling.
Int J Infect Dis
; 144: 107053, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38641317
ABSTRACT
BACKGROUND:
Vietnam continues to have measles and rubella outbreaks following supplementary immunization activities (SIA) and routine immunization despite both having high reported coverage. To evaluate immunization activities, age-specific immunity against measles and rubella, and the number of averted Congenital Rubella Syndrome (CRS) cases, must be estimated.METHODS:
Dried blood spots were collected from 2091 randomly selected individuals aged 1-39 years. Measles and rubella virus-specific immunoglobulin G (IgG) were measured by enzyme immunoassay. Results were considered positive at ≥120 mIU/mL for measles and ≥10 IU/mL for rubella. The number of CRS cases averted by immunization since 2014 were estimated using mathematical modelling.RESULTS:
Overall IgG seroprevalence was 99.7% (95%CI 99.2-99.9) for measles and 83.6% (95%CI 79.3-87.1) for rubella. Rubella IgG seroprevalence was higher among age groups targeted in the SIA than in non-targeted young adults (95.4% [95%CI 92.9-97.0] vs 72.4% [95%CI 63.1-80.1]; P < 0.001). The estimated number of CRS cases averted in 2019 by immunization activities since 2014 ranged from 126 (95%CI 0-460) to 883 (95%CI 0-2271) depending on the assumed postvaccination reduction in the force of infection.CONCLUSIONS:
The results suggest the SIA was effective, while young adults born before 1998 who remain unprotected for rubella require further vaccination.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Rubéola (Sarampión Alemán)
/
Inmunoglobulina G
/
Sarampión
/
Anticuerpos Antivirales
Idioma:
En
Revista:
Int J Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2024
Tipo del documento:
Article