Spatially fractionated radiation therapy: a critical review on current status of clinical and preclinical studies and knowledge gaps.
Phys Med Biol
; 69(10)2024 May 10.
Article
en En
| MEDLINE
| ID: mdl-38648789
ABSTRACT
Spatially fractionated radiation therapy (SFRT) is a therapeutic approach with the potential to disrupt the classical paradigms of conventional radiation therapy. The high spatial dose modulation in SFRT activates distinct radiobiological mechanisms which lead to a remarkable increase in normal tissue tolerances. Several decades of clinical use and numerous preclinical experiments suggest that SFRT has the potential to increase the therapeutic index, especially in bulky and radioresistant tumors. To unleash the full potential of SFRT a deeper understanding of the underlying biology and its relationship with the complex dosimetry of SFRT is needed. This review provides a critical analysis of the field, discussing not only the main clinical and preclinical findings but also analyzing the main knowledge gaps in a holistic way.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fraccionamiento de la Dosis de Radiación
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Phys Med Biol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Francia