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Synchronized Expansion and Contraction of Olfactory, Vomeronasal, and Taste Receptor Gene Families in Hystricomorph Rodents.
Niimura, Yoshihito; Biswa, Bhim B; Kishida, Takushi; Toyoda, Atsushi; Fujiwara, Kazumichi; Ito, Masato; Touhara, Kazushige; Inoue-Murayama, Miho; Jenkins, Scott H; Adenyo, Christopher; Kayang, Boniface B; Koide, Tsuyoshi.
Afiliación
  • Niimura Y; Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
  • Biswa BB; Mouse Genomics Resource Laboratory, National Institute of Genetics, Mishima, Japan.
  • Kishida T; Department of Genetics, SOKENDAI (The Graduate University for Advanced Studies), Shizuoka, Japan.
  • Toyoda A; Curatorial Division, Museum of Natural and Environmental History, Shizuoka, Japan.
  • Fujiwara K; Present address: College of Bioresource Sciences, Nihon University, Fujisawa, Japan.
  • Ito M; Comparative Genomics Laboratory, National Institute of Genetics, Shizuoka, Japan.
  • Touhara K; Mouse Genomics Resource Laboratory, National Institute of Genetics, Mishima, Japan.
  • Inoue-Murayama M; Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
  • Jenkins SH; Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
  • Adenyo C; Wildlife Research Center, Kyoto University, Kyoto, Japan.
  • Kayang BB; Wildlife Research Center, Kyoto University, Kyoto, Japan.
  • Koide T; Present address: Biosphere Informatics Laboratory, Department of Social Informatics, Graduate School of Informatics, Kyoto, Japan.
Mol Biol Evol ; 41(4)2024 Apr 02.
Article en En | MEDLINE | ID: mdl-38649162
ABSTRACT
Chemical senses, including olfaction, pheromones, and taste, are crucial for the survival of most animals. There has long been a debate about whether different types of senses might influence each other. For instance, primates with a strong sense of vision are thought to have weakened olfactory abilities, although the oversimplified trade-off theory is now being questioned. It is uncertain whether such interactions between different chemical senses occur during evolution. To address this question, we examined four receptor gene families related to olfaction, pheromones, and taste olfactory receptor (OR), vomeronasal receptor type 1 and type 2 (V1R and V2R), and bitter taste receptor (T2R) genes in Hystricomorpha, which is morphologically and ecologically the most diverse group of rodents. We also sequenced and assembled the genome of the grasscutter, Thryonomys swinderianus. By examining 16 available genome assemblies alongside the grasscutter genome, we identified orthologous gene groups among hystricomorph rodents for these gene families to separate the gene gain and loss events in each phylogenetic branch of the Hystricomorpha evolutionary tree. Our analysis revealed that the expansion or contraction of the four gene families occurred synchronously, indicating that when one chemical sense develops or deteriorates, the others follow suit. The results also showed that V1R/V2R genes underwent the fastest evolution, followed by OR genes, and T2R genes were the most evolutionarily stable. This variation likely reflects the difference in ligands of V1R/V2Rs, ORs, and T2Rs species-specific pheromones, environment-based scents, and toxic substances common to many animals, respectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Roedores / Familia de Multigenes / Receptores Odorantes / Evolución Molecular / Órgano Vomeronasal Límite: Animals Idioma: En Revista: Mol Biol Evol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Roedores / Familia de Multigenes / Receptores Odorantes / Evolución Molecular / Órgano Vomeronasal Límite: Animals Idioma: En Revista: Mol Biol Evol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Japón
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