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Vitamin D regulates microbiome-dependent cancer immunity.
Giampazolias, Evangelos; Pereira da Costa, Mariana; Lam, Khiem C; Lim, Kok Haw Jonathan; Cardoso, Ana; Piot, Cécile; Chakravarty, Probir; Blasche, Sonja; Patel, Swara; Biram, Adi; Castro-Dopico, Tomas; Buck, Michael D; Rodrigues, Richard R; Poulsen, Gry Juul; Palma-Duran, Susana A; Rogers, Neil C; Koufaki, Maria A; Minutti, Carlos M; Wang, Pengbo; Vdovin, Alexander; Frederico, Bruno; Childs, Eleanor; Lee, Sonia; Simpson, Ben; Iseppon, Andrea; Omenetti, Sara; Kelly, Gavin; Goldstone, Robert; Nye, Emma; Suárez-Bonnet, Alejandro; Priestnall, Simon L; MacRae, James I; Zelenay, Santiago; Patil, Kiran Raosaheb; Litchfield, Kevin; Lee, James C; Jess, Tine; Goldszmid, Romina S; Reis E Sousa, Caetano.
Afiliación
  • Giampazolias E; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Pereira da Costa M; Cancer Immunosurveillance Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.
  • Lam KC; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Lim KHJ; Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology (LICI), Center for Cancer Research (CCR), National Cancer Institute (NCI), Bethesda, MD 20892, USA.
  • Cardoso A; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Piot C; Department of Immunology and Inflammation, Imperial College London, London SW7 2AZ, UK.
  • Chakravarty P; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Blasche S; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Patel S; Bioinformatics and Biostatistics STP, The Francis Crick Institute, London NW1 1AT, UK.
  • Biram A; MRC Toxicology Unit, University of Cambridge, Cambridge CB2 1QR, UK.
  • Castro-Dopico T; Cancer Immunosurveillance Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.
  • Buck MD; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Rodrigues RR; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Poulsen GJ; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Palma-Duran SA; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  • Rogers NC; Microbiome and Genetics Core, LICI, CCR, NCI, Bethesda, MD 20892, USA.
  • Koufaki MA; National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease, PREDICT, Faculty of Medicine, Aalborg University, Department of Gastroenterology and Hepatology, Aalborg University Hospital, A DK-2450 Copenhagen, Denmark.
  • Minutti CM; Metabolomics STP, The Francis Crick Institute, London NW1 1AT, UK.
  • Wang P; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Vdovin A; Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.
  • Frederico B; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Childs E; Cancer Immunosurveillance Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.
  • Lee S; Cancer Immunosurveillance Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.
  • Simpson B; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Iseppon A; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Omenetti S; Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Kelly G; Tumor Immunogenomics and Immunosurveillance (TIGI) Lab, UCL Cancer Institute, London WC1E 6DD, UK.
  • Goldstone R; AhRimmunity Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Nye E; AhRimmunity Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Suárez-Bonnet A; Bioinformatics and Biostatistics STP, The Francis Crick Institute, London NW1 1AT, UK.
  • Priestnall SL; Bioinformatics and Biostatistics STP, The Francis Crick Institute, London NW1 1AT, UK.
  • MacRae JI; Experimental Histopathology, The Francis Crick Institute, London NW1 1AT, UK.
  • Zelenay S; Experimental Histopathology, The Francis Crick Institute, London NW1 1AT, UK.
  • Patil KR; Department of Pathobiology and Population Sciences, The Royal Veterinary College, North Mimms, Hatfield, Hertfordshire AL9 7TA, UK.
  • Litchfield K; Experimental Histopathology, The Francis Crick Institute, London NW1 1AT, UK.
  • Lee JC; Department of Pathobiology and Population Sciences, The Royal Veterinary College, North Mimms, Hatfield, Hertfordshire AL9 7TA, UK.
  • Jess T; Metabolomics STP, The Francis Crick Institute, London NW1 1AT, UK.
  • Goldszmid RS; Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.
  • Reis E Sousa C; MRC Toxicology Unit, University of Cambridge, Cambridge CB2 1QR, UK.
Science ; 384(6694): 428-437, 2024 Apr 26.
Article en En | MEDLINE | ID: mdl-38662827
ABSTRACT
A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to transplantable cancers and augmented responses to checkpoint blockade immunotherapies. Similarly, in humans, vitamin D-induced genes correlate with improved responses to immune checkpoint inhibitor treatment as well as with immunity to cancer and increased overall survival. In mice, resistance is attributable to the activity of vitamin D on intestinal epithelial cells, which alters microbiome composition in favor of Bacteroides fragilis, which positively regulates cancer immunity. Our findings indicate a previously unappreciated connection between vitamin D, microbial commensal communities, and immune responses to cancer. Collectively, they highlight vitamin D levels as a potential determinant of cancer immunity and immunotherapy success.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacteroides fragilis / Vitamina D / Microbioma Gastrointestinal / Inhibidores de Puntos de Control Inmunológico / Neoplasias Límite: Animals / Female / Humans / Male Idioma: En Revista: Science Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacteroides fragilis / Vitamina D / Microbioma Gastrointestinal / Inhibidores de Puntos de Control Inmunológico / Neoplasias Límite: Animals / Female / Humans / Male Idioma: En Revista: Science Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido