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A Multivariant Surrogate Virus Neutralization Test Demonstrates Distinct SARS-CoV-2-Specific Antibody Responses in People Living with HIV after a Fourth Monovalent mRNA Vaccination or an Omicron Breakthrough Infection.
Springer, David Niklas; Daller, Simon; Knappik, Michael; Prüger, Katja; Hartl, Sylvia; Breyer-Kohansal, Robab; Puchhammer-Stöckl, Elisabeth; Aberle, Judith Helene; Weseslindtner, Lukas; Breyer, Marie Kathrin.
Afiliación
  • Springer DN; Center for Virology, Medical University of Vienna, 1090 Vienna, Austria.
  • Daller S; Department of Respiratory and Pulmonary Diseases, Vienna Healthcare Group, Clinic Penzing, 1140 Vienna, Austria.
  • Knappik M; Department of Respiratory and Pulmonary Diseases, Vienna Healthcare Group, Clinic Penzing, 1140 Vienna, Austria.
  • Prüger K; Center for Virology, Medical University of Vienna, 1090 Vienna, Austria.
  • Hartl S; Department of Respiratory and Pulmonary Diseases, Vienna Healthcare Group, Clinic Penzing, 1140 Vienna, Austria.
  • Breyer-Kohansal R; Ludwig Boltzmann Institute for Lung Health, 1140 Vienna, Austria.
  • Puchhammer-Stöckl E; Faculty of Medicine, Sigmund Freud University, 1020 Vienna, Austria.
  • Aberle JH; Department of Respiratory and Pulmonary Diseases, Vienna Healthcare Group, Clinic Penzing, 1140 Vienna, Austria.
  • Weseslindtner L; Ludwig Boltzmann Institute for Lung Health, 1140 Vienna, Austria.
  • Breyer MK; Center for Virology, Medical University of Vienna, 1090 Vienna, Austria.
Diagnostics (Basel) ; 14(8)2024 Apr 16.
Article en En | MEDLINE | ID: mdl-38667468
ABSTRACT
While neutralizing antibodies (nAbs) induced by monovalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations are primarily directed against the wildtype (WT), subsequent exposure to the Omicron variants may increase the breadth of the antibodies' cross-neutralizing activity. Here, we analyzed the impact of an Omicron breakthrough infection (BTI) or a fourth monovalent mRNA vaccination on nAb profiles in people living with human immunodeficiency virus (PLWH). Using a multivariant surrogate virus neutralization test (sVNT), we quantified nAbs in 36 three-times vaccinated PLWH, of whom 9 acquired a serologically confirmed Omicron BTI, 8 received a fourth vaccine dose, and 19 were neither infected nor additionally vaccinated. While nAbs against WT and Delta increased after the BTI and a fourth vaccination, a significant increase against BA.1, BA.2, and BA.5 was only observed after the BTI. However, there was no significant difference in nAb concentrations between the samples obtained after the BTI and fourth vaccination. In contrast, nAb levels were significantly lower in PLWH, who were neither infected nor additionally vaccinated after three vaccinations. Thus, our study demonstrates the suitability of a multivariant sVNT to assess hybrid humoral immunity after Omicron BTIs in PLWH vaccinated against SARS-CoV-2.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diagnostics (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Austria

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diagnostics (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Austria
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