Cognition and Other Non-Motor Symptoms in an At-Risk Cohort for Parkinson's Disease Defined by REM-Sleep Behavior Disorder and Hyposmia.
J Parkinsons Dis
; 14(3): 545-556, 2024.
Article
en En
| MEDLINE
| ID: mdl-38669560
ABSTRACT
Background:
REM-sleep behavior disorder (RBD) and other non-motor symptoms such as hyposmia were proposed by the Movement Disorder Society as research criteria for prodromal Parkinson's disease (P-PD). Global cognitive deficit was later added.Objective:
To compare non-motor symptoms, focusing on cognition, between a P-PD group and a matched control group.Methods:
In this cross-sectional, case-control study, in a first set of analyses, we performed extensive cognitive testing on people with (nâ=â76) and a control group without (nâ=â195) probable RBD and hyposmia. Furthermore, we assessed motor and non-motor symptoms related to Parkinson's Disease (PD). After propensity score matching, we compared 62 P-PD with 62 age- and sex-matched controls. In addition, we performed regression analyses on the total sample (nâ=â271). In a second set of analyses, we used, a.o., the CUPRO to evaluate retrograde procedural memory and visuo-constructive functions.Results:
People with P-PD showed significantly poorer performances in global cognition, visuo-constructive and executive functions, mainly in mental flexibility (pâ<â0.001; pâ=â0.004; pâ=â0.003), despite similar educational levels (pâ=â0.415). We observed significantly more motor and non-motor symptoms (pâ<â0.001; pâ=â0.004), higher scores for depression (pâ=â0.004) and apathy (pâ<â0.001) as well as lower quality of life (pâ<â0.001) in P-PD.CONCLUSIONS:
Our findings confirm that global cognitive, executive, and visuo-constructive deficits define the P-PD group. In addition, depression, apathy, and lower quality of life were more prevalent in P-PD. If replicated in other samples, executive and visuo-constructive deficits should be considered in non-motor P-PD. Determining specific patterns will support early recognition of PD, secondary prevention of complications and the development of neuroprotective treatments.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
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Trastorno de la Conducta del Sueño REM
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Disfunción Cognitiva
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Anosmia
Límite:
Aged
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Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Parkinsons Dis
Año:
2024
Tipo del documento:
Article
País de afiliación:
Luxemburgo