Signaling by Type I Interferons in Immune Cells: Disease Consequences.

Zannikou, Markella; Fish, Eleanor N; Platanias, Leonidas C

Zannikou, Markella; Fish, Eleanor N; Platanias, Leonidas C.

Afiliación

Zannikou M; Robert H. Lurie Comprehensive Cancer Center, Division of Hematology-Oncology, Feinberg School of Medicine, Northwestern University, 303 East Superior Ave., Chicago, IL 60611, USA.
Fish EN; Toronto General Hospital Research Institute, University Health Network, 67 College Street, Toronto, ON M5G 2M1, Canada.
Platanias LC; Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.

Cancers (Basel) ; 16(8)2024 Apr 22.

Article en En | MEDLINE | ID: mdl-38672681

ABSTRACT

ABSTRACT

This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-tumor activity and promoting cancer progression. We discuss the abnormal IFN signaling induced by cancerous cells that alters immune responses to permit their survival and proliferation.

Palabras clave

B cells; NK cells; T cell; cancer; dendritic cell; immune cells; interferons; macrophage; neutrophils; signaling; tumor microenvironment

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

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