Engineering of electrospun polycaprolactone/polyvinyl alcohol-collagen based 3D nano scaffolds and their drug release kinetics using cetirizine as a model drug.

ABSTRACT

Combining the versatility of electrospinning with the biocompatibility of Polycaprolactone and Collagen, this study aims to create advanced 3D nano scaffolds for effective drug delivery. Ceramic materials like hydroxyapatite (nHAp) are incorporated as bioactive agents in the fibers. Electrospun PCL (Polycaprolactone)/collagen nanofibers and PVA (Poly-vinyl alcohol)/collagen are promising tissue-engineering substitutes with high biocompatibility, low cytotoxicity, and great tensile strength. Small pores in these nanofibers play a major role in drug delivery system. Owing to its short half-life, limited solubility, restricted bioavailability as well as re-crystallization concerns, the application of Cetirizine (CIT) has found little relevance. Electrospun nanofibers impregnated with CIT provide an excellent solution to combat these limitations, yield sustained drug release along with hampering drug re-crystallization. CIT-loaded polyvinyl alcohol (PVA)/collagen (Col) and CIT-loaded PVA/Col/nHAp nanofibers were characterized and further CIT anti-crystallization as well as release behaviors were investigated. FESEM and HRTEM were used to observe the morphology of the as-synthesized nanofibers. FTIR spectroscopy, water contact angle measurement and drug release studies verified the differences in performance of CIT-loaded PVA/Col and PVA/Col/nHAp nanofibers. The release trend of CIT through these as-synthesized nanoscaffolds was analyzed by various kinetic models and exhibited sustained release of CIT for up to 96 h.