[Research Progress in the Roles of MRE11-RAD50-NBS1 Complex and Human Diseases].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
; 46(2): 232-241, 2024 Apr.
Article
en Zh
| MEDLINE
| ID: mdl-38686720
ABSTRACT
DNA is susceptible to various factors in vitro and in vivo and experience different forms of damage,among which double-strand break(DSB)is a deleterious form.To maintain the stability of genetic information,organisms have developed multiple mechanisms to repair DNA damage.Among these mechanisms,homologous recombination(HR)is praised for the high accuracy.The MRE11-RAD50-NBS1(MRN)complex plays an important role in HR and is conserved across different species.The knowledge on the MRN complex mainly came from the previous studies in Saccharomyces cerevisiae and Caenorhabditis elegans,while studies in the last decades have revealed the role of mammalian MRN complex in DNA repair of higher animals.In this review,we first introduces the MRN complex regarding the composition,structure,and roles in HR.In addition,we discuss the human diseases such as ataxia-telangiectasia-like disorder,Nijmegen breakage syndrome,and Nijmegen breakage syndrome-like disorder that are caused by dysfunctions in the MRN complex.Furthermore,we summarize the mouse models established to study the clinical phenotypes of the above diseases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Nucleares
/
Ácido Anhídrido Hidrolasas
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Proteínas de Ciclo Celular
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Enzimas Reparadoras del ADN
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Proteínas de Unión al ADN
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Proteína Homóloga de MRE11
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
Año:
2024
Tipo del documento:
Article
País de afiliación:
China