Mineralocorticoid receptor antagonists in heart failure with reduced ejection fraction: a systematic review and network meta-analysis of 32 randomized trials.
Curr Probl Cardiol
; 49(7): 102615, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38692445
ABSTRACT
INTRODUCTION:
Several randomized controlled trials (RCTs) have examined mineralocorticoid receptor antagonists (MRAs) in heart failure (HF) with reduced ejection fraction (HFrEF). This systematic review and network meta-analysis (NMA) evaluated the comparative efficacy and safety of MRAs in HFrEF. MATERIALS ANDMETHODS:
MEDLINE(Pubmed), Scopus, Cochrane and ClinicalTrials.gov were searched until April 8, 2024 for RCTs examining the efficacy and/or safety of MRAs in HFrEF. Double-independent study selection, extraction and quality assessment were performed. Random-effects frequentist NMA models were used. Evidence certainty was assessed via Grading of Recommendations Assessment, Development and Evaluation (GRADE).RESULTS:
Totally, 32 RCTs (15685 patients) were analyzed. Eplerenone ranked above spironolactone in all-cause mortality (hazard ratio {HR}=0.78, 95% confidence interval {CI} [0.66,0.91], GRADE"Moderate"), cardiovascular death (HR=0.74, 95%CI [0.53, 1.04], GRADE"Low") and in all safety outcomes. Spironolactone was superior to eplerenone in the composite of cardiovascular death or hospitalization (HR=0.67, 95%CI [0.50,0.89], GRADE"Moderate"), HF hospitalization (HR=0.61, 95%CI [0.43,0.86], GRADE"Moderate"), all-cause hospitalization (HR=0.51, 95%CI [0.26,0.98], GRADE"Moderate") and cardiovascular hospitalization (HR=0.56, 95%CI [0.37,0.84], GRADE"Moderate"). Canrenone ranked first in all-cause mortality, the composite outcome and HF hospitalization. Finerenone ranked first in hyperkalemia (risk ratio [RR]=1.56, 95%CI [0.89,2.74], GRADE"Moderate"), renal injury (RR=0.56, 95%CI [0.24,1.29]), any adverse event (RR=0.84, 95%CI [0.75,0.94], GRADE"Moderate"), treatment discontinuation (RR=0.89, 95%CI [0.64,1.23]) and hypotension (RR=1.06, 95%CI [0.12,9.41]).CONCLUSIONS:
MRAs are effective in HFrEF with certain safety disparities. Spironolactone and eplerenone exhibited similar efficacy, however, eplerenone demonstrated superior safety. Finerenone was the safest MRA, while canrenone exhibited considerable efficacy, nonetheless, evidence for these MRAs were scarce.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Volumen Sistólico
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Ensayos Clínicos Controlados Aleatorios como Asunto
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Antagonistas de Receptores de Mineralocorticoides
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Metaanálisis en Red
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Insuficiencia Cardíaca
Límite:
Humans
Idioma:
En
Revista:
Curr Probl Cardiol
Año:
2024
Tipo del documento:
Article