Neurofibroma with glomus-like bodies: A novel association-Thoughts about origin.
J Cutan Pathol
; 51(8): 594-597, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38698729
ABSTRACT
A neurofibroma with focal glomus-like body differentiation is an unusual phenomenon recently encountered in an excision specimen from the right lateral distal forearm of a 26-year-old man. Glomus cells are modified smooth muscle cells normally present in glomus-like bodies but can also be found in glomus tumors (GT) or lesions considered in the spectrum of GT, including myopericytoma, myofibroma, and angiolipoma. Neurofibromas are peripheral nerve sheath tumors derived from the neural crest cells. While both GT and its variants and neurofibroma are thought to be derived from different cell types, there is growing evidence that glomus cells have a neural crest origin. This is based on multiple theories, with some overlapping pathways, including neural crest cell differentiation, Schwann cell reprogramming, VEGF expression, and NF1 gene biallelic inactivation. This report adds to the growing evidence of possible neural crest origin for glomus cells and would help explain finding glomus-like bodies scattered through a neurofibroma.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tumor Glómico
/
Neurofibroma
Límite:
Adult
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Humans
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Male
Idioma:
En
Revista:
J Cutan Pathol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos