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Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization.
García-Poyatos, Carolina; Arora, Prateek; Calvo, Enrique; Marques, Ines J; Kirschke, Nick; Galardi-Castilla, Maria; Lembke, Carla; Meer, Marco; Fernández-Montes, Paula; Ernst, Alexander; Haberthür, David; Hlushchuk, Ruslan; Vázquez, Jesús; Vermathen, Peter; Enríquez, José Antonio; Mercader, Nadia.
Afiliación
  • García-Poyatos C; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain; Centro de Investigación Biomédica en red en Fragilidad y Envejecimiento saludable (CIBERFES), Madrid, Spain.
  • Arora P; Department of Developmental Biology and Regeneration, Institute of Anatomy, University of Bern, Bern, Switzerland; Department for Biomedical Research, Cardiovascular Disease Program, University of Bern, Bern, Switzerland.
  • Calvo E; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain; Centro de Investigación Biomédica en red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
  • Marques IJ; Department of Developmental Biology and Regeneration, Institute of Anatomy, University of Bern, Bern, Switzerland; Department for Biomedical Research, Cardiovascular Disease Program, University of Bern, Bern, Switzerland.
  • Kirschke N; Department of Developmental Biology and Regeneration, Institute of Anatomy, University of Bern, Bern, Switzerland; Department for Biomedical Research, Cardiovascular Disease Program, University of Bern, Bern, Switzerland.
  • Galardi-Castilla M; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
  • Lembke C; Department of Developmental Biology and Regeneration, Institute of Anatomy, University of Bern, Bern, Switzerland; Department for Biomedical Research, Cardiovascular Disease Program, University of Bern, Bern, Switzerland.
  • Meer M; Department of Developmental Biology and Regeneration, Institute of Anatomy, University of Bern, Bern, Switzerland; Department for Biomedical Research, Cardiovascular Disease Program, University of Bern, Bern, Switzerland.
  • Fernández-Montes P; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
  • Ernst A; Department of Developmental Biology and Regeneration, Institute of Anatomy, University of Bern, Bern, Switzerland.
  • Haberthür D; MicroCT research group, Institute of Anatomy, University of Bern, Bern, Switzerland.
  • Hlushchuk R; MicroCT research group, Institute of Anatomy, University of Bern, Bern, Switzerland.
  • Vázquez J; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain; Centro de Investigación Biomédica en red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
  • Vermathen P; University Institute of Diagnostic and Interventional Neuroradiology, Magnetic Resonance Methodology, University of Bern, Bern, Switzerland.
  • Enríquez JA; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain; Centro de Investigación Biomédica en red en Fragilidad y Envejecimiento saludable (CIBERFES), Madrid, Spain. Electronic address: jaenriquez@cnic.es.
  • Mercader N; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain; Department of Developmental Biology and Regeneration, Institute of Anatomy, University of Bern, Bern, Switzerland; Department for Biomedical Research, Cardiovascular Disease Program, University of Bern, Bern, Switzerland.
Dev Cell ; 59(14): 1824-1841.e10, 2024 Jul 22.
Article en En | MEDLINE | ID: mdl-38701784
ABSTRACT
The oxidative phosphorylation (OXPHOS) system is intricately organized, with respiratory complexes forming super-assembled quaternary structures whose assembly mechanisms and physiological roles remain under investigation. Cox7a2l, also known as Scaf1, facilitates complex III and complex IV (CIII-CIV) super-assembly, enhancing energetic efficiency in various species. We examined the role of Cox7a1, another Cox7a family member, in supercomplex assembly and muscle physiology. Zebrafish lacking Cox7a1 exhibited reduced CIV2 formation, metabolic alterations, and non-pathological muscle performance decline. Additionally, cox7a1-/- hearts displayed a pro-regenerative metabolic profile, impacting cardiac regenerative response. The distinct phenotypic effects of cox7a1-/- and cox7a2l-/- underscore the diverse metabolic and physiological consequences of impaired supercomplex formation, emphasizing the significance of Cox7a1 in muscle maturation within the OXPHOS system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosforilación Oxidativa / Regeneración / Pez Cebra / Complejo IV de Transporte de Electrones / Músculo Esquelético / Proteínas de Pez Cebra / Corazón Límite: Animals Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: España
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosforilación Oxidativa / Regeneración / Pez Cebra / Complejo IV de Transporte de Electrones / Músculo Esquelético / Proteínas de Pez Cebra / Corazón Límite: Animals Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: España