Maternal residential exposure to solvents from industrial sources during pregnancy and childhood cancer risk in California.
Int J Hyg Environ Health
; 259: 114388, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38704950
ABSTRACT
BACKGROUND:
Maternal solvent exposure has been suspected to increase offspring cancer risk. The study aimed to evaluate the associations between maternal residential exposure to solvents from industrial pollution during pregnancy and childhood cancer.METHODS:
The present study included 15,744 cancer cases (aged 0-19 years at diagnosis) identified from California Cancer Registry and 283,141 controls randomly selected from California Birth Registry (201 frequency-matched by birth year 1998-2016). We examined industrial releases of tetrachloroethylene and 1,1,1-trichloroethane within 3 km of the birth address, while we used a 5 km buffer for carbon disulfide. We calculated the total exposure from all linked Toxic Release Inventory sites during each index pregnancy and assigned "ever/never" and "high/low exposed/unexposed" exposure, using median values. We performed quadratic decay models to estimate cancer risks associated with maternal solvent exposure in pregnancy.RESULTS:
1,1,1-Trichloroethane was associated with rhabdomyosarcoma (adjusted Odds Ratio (aOR) 1.96; 95% Confidence Interval (CI) 1.16, 3.32) in the "ever exposed" group. Ever exposure to carbon disulfide was associated with increased risks of medulloblastoma (OR = 1.85, 95% CI 1.01, 3.40) and ependymoma (OR = 1.63, 95% CI 0.97, 2.74).CONCLUSIONS:
Overall, our findings suggested maternal residential exposure to solvents from industrial sources might be associated with elevated childhood cancer risks.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Solventes
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Exposición Materna
/
Neoplasias
Límite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
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Pregnancy
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Int J Hyg Environ Health
Asunto de la revista:
SAUDE AMBIENTAL
/
SAUDE PUBLICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos