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Paediatric non-infectious granulomatous uveitis: a retrospective cohort study.
Nguyen, Ai Tien; Rousseau, Antoine; Bodaghi, Bahram; Rossi-Semerano, Linda; Galeotti, Caroline; Da Cunha, Elodie; Eid, Laura; Labetoulle, Marc; Barreau, Emmanuel; Titah, Cherif; Toutée, Adélaïde; Koné-Paut, Isabelle; Dusser, Perrine; Borocco, Charlotte.
Afiliación
  • Nguyen AT; Department of Paediatric Rheumatology, CeReMAIA, ERN RITA member, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Saclay University, Le Kremlin-Bicêtre, France.
  • Rousseau A; Department of Ophthalmology, OPHTARA, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Saclay University, Le Kremlin-Bicêtre, France.
  • Bodaghi B; IDMIT Infrastructure, CEA, Paris-Saclay University, Inserm U1184, Fontenay-aux-Roses, France.
  • Rossi-Semerano L; Department of Ophthalmology, la Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Galeotti C; Department of Paediatric Rheumatology, CeReMAIA, ERN RITA member, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Saclay University, Le Kremlin-Bicêtre, France.
  • Da Cunha E; Department of Paediatric Rheumatology, CeReMAIA, ERN RITA member, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Saclay University, Le Kremlin-Bicêtre, France.
  • Eid L; Department of Ophthalmology, OPHTARA, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Saclay University, Le Kremlin-Bicêtre, France.
  • Labetoulle M; Department of Ophthalmology, OPHTARA, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Saclay University, Le Kremlin-Bicêtre, France.
  • Barreau E; Department of Ophthalmology, OPHTARA, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Saclay University, Le Kremlin-Bicêtre, France.
  • Titah C; IDMIT Infrastructure, CEA, Paris-Saclay University, Inserm U1184, Fontenay-aux-Roses, France.
  • Toutée A; Department of Ophthalmology, OPHTARA, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Saclay University, Le Kremlin-Bicêtre, France.
  • Koné-Paut I; Department of Ophthalmology, Adolphe de Rothschild Hospital, Paris, France.
  • Dusser P; Department of Ophthalmology, la Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Borocco C; Department of Paediatric Rheumatology, CeReMAIA, ERN RITA member, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Saclay University, Le Kremlin-Bicêtre, France.
Article en En | MEDLINE | ID: mdl-38710493
ABSTRACT

INTRODUCTION:

Paediatric granulomatous uveitis (PGU) is rare. In addition, lack of awareness often leads to delayed diagnosis and poor visual outcome. Identifying the underlying cause and deciding how best to treat each patient is challenging.

OBJECTIVES:

To evaluate the demographics, aetiologies, complications, treatments, and visual prognosis of paediatric non-infectious granulomatous uveitis.

METHODS:

Retrospective chart review of non-infectious PGU occurring in children before the age of 16 years recruited from the Paediatric Rheumatology Unit, Bicêtre Hospital, France, from 2001 to 2023.

RESULTS:

We included 50 patients with 90 affected eyes 29 with idiopathic uveitis, 15 with sarcoidosis, 5 with juvenile idiopathic arthritis, and one with Vogt-Koyanagi-Harada disease. Median age at diagnosis was 9.8 years (range 7.2-12.5). The sex-ratio M/F was 0.52. The most common features of PGU were panuveitis (56%), bilateral (84%), and chronic (84%). Sarcoidosis was the most frequent diagnosis after idiopathic disease, particularly in the presence of lymphopenia and hypergammaglobulinemia. Uveomeningitis was present in 12% of cases. Upon diagnosis, ocular complications were present in 68 of 90 eyes (76%) particularly in cases of panuveitis. The most commonly used treatments were systemic corticosteroids (72%) and methotrexate (80%). Twenty-three percent of eyes were in remission at last follow-up, 68% were inactive and 4% remained active. The median duration of follow-up was 5.8 years.

CONCLUSION:

We report the largest cohort of PGU. PGU were mostly idiopathic and had a high rate of complications. Sarcoid and idiopathic panuveitis are serious illnesses in which disease-modifying therapy should be initiated at diagnosis to improve management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Francia
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