Early signaling pathways in virus-infected cells.
Curr Opin Virol
; 66: 101411, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38718574
ABSTRACT
Virus infection activates specific pattern recognition receptors and immune signal transduction, resulting in pro-inflammatory cytokine production and activation of innate immunity. We describe here the molecular organization of early signaling pathways downstream of viral recognition, including conformational changes, post-translational modifications, formation of oligomers, and generation of small-molecule second messengers. Such molecular organization allows tight regulation of immune signal transduction, characterized by swift but transient responses, nonlinearity, and signal amplification. Pathologies of early immune signaling caused by genomic mutations illustrate the fine regulation of the immune transduction cascade.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virosis
/
Transducción de Señal
/
Inmunidad Innata
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Virol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Francia