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Boswellic Acid and Betulinic Acid Pre-treatments Can Prevent the Nephrotoxicity Caused by Cyclophosphamide Induction.
Berköz, Mehmet; Çiftçi, Oguzhan.
Afiliación
  • Berköz M; Department of Biochemistry, Faculty of Pharmacy, Van Yuzuncu Yil University, Van, Turkey. mehmet_berkoz@yahoo.com.
  • Çiftçi O; Department of Biochemistry, Faculty of Pharmacy, Van Yuzuncu Yil University, Van, Turkey.
Dokl Biochem Biophys ; 517(1): 115-126, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38744737
ABSTRACT
Cyclophosphamide (CYP) is a chemotherapeutic drug used to treat various cancers. However, its clinical use is limited due to severe organ damage, particularly to the kidneys. While several phytochemicals have been identified as potential therapeutic targets for CYP nephrotoxicity, the nephroprotective effects of boswellic acid (BOSW) and betulinic acid (BET) have not yet been investigated. Our study used 42 rats divided into six equal groups. The study included six groups control, CYP (200 mg/kg), CYP+BOSW20 (20 mg/kg), CYP+BOSW40 (40 mg/kg), CYP+BET20 (20 mg/kg), and CYP+BET40 (40 mg/kg). The pre-treatments with BOSW and BET lasted for 14 days, while the application of cyclophosphamide was performed intraperitoneally only on the 4th day of the study. After the experimental protocol, the animals were sacrificed, and their kidney tissues were isolated. Renal function parameters, histological examination, oxidative stress, and inflammation parameters were assessed both biochemically and at the molecular level in kidney tissue. The results showed that oxidative stress and inflammatory response were increased in the kidney tissue of rats treated with CYP, leading to impaired renal histology and function parameters (p < 0.05). Oral administration of both doses of BET and especially high doses of BOSW improved biochemical, oxidative, and inflammatory parameters significantly (p < 0.05). Histological studies also showed the restoration of normal kidney tissue architecture. BOSW and BET have promising biological activity against CYP-induced nephrotoxicity by attenuating inflammation and oxidative stress and enhancing antioxidant status.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triterpenos / Estrés Oxidativo / Ciclofosfamida / Triterpenos Pentacíclicos / Ácido Betulínico / Riñón Límite: Animals Idioma: En Revista: Dokl Biochem Biophys Asunto de la revista: BIOFISICA / BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Turquía

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triterpenos / Estrés Oxidativo / Ciclofosfamida / Triterpenos Pentacíclicos / Ácido Betulínico / Riñón Límite: Animals Idioma: En Revista: Dokl Biochem Biophys Asunto de la revista: BIOFISICA / BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Turquía
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