Priming central sound processing circuits through induction of spontaneous activity in the cochlea before hearing onset.
Trends Neurosci
; 47(7): 522-537, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38782701
ABSTRACT
Sensory systems experience a period of intrinsically generated neural activity before maturation is complete and sensory transduction occurs. Here we review evidence describing the mechanisms and functions of this 'spontaneous' activity in the auditory system. Both ex vivo and in vivo studies indicate that this correlated activity is initiated by non-sensory supporting cells within the developing cochlea, which induce depolarization and burst firing of groups of nearby hair cells in the sensory epithelium, activity that is conveyed to auditory neurons that will later process similar sound features. This stereotyped neural burst firing promotes cellular maturation, synaptic refinement, acoustic sensitivity, and establishment of sound-responsive domains in the brain. While sensitive to perturbation, the developing auditory system exhibits remarkable homeostatic mechanisms to preserve periodic burst firing in deaf mice. Preservation of this early spontaneous activity in the context of deafness may enhance the efficacy of later interventions to restore hearing.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cóclea
/
Audición
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Neurosci
/
Trends in neurosciences
/
Trends neurosci
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos