Contribution of neurophysiology to the diagnosis and monitoring of ALS.
Int Rev Neurobiol
; 176: 87-118, 2024.
Article
en En
| MEDLINE
| ID: mdl-38802184
ABSTRACT
This chapter describes the role of neurophysiological techniques in diagnosing and monitoring amyotrophic lateral sclerosis (ALS). Despite many advances, electromyography (EMG) remains a keystone investigation from which to build support for a diagnosis of ALS, demonstrating the pathophysiological processes of motor unit hyperexcitability, denervation and reinnervation. We consider development of the different diagnostic criteria and the role of EMG therein. While not formally recognised by established diagnostic criteria, we discuss the pioneering studies that have demonstrated the diagnostic potential of transcranial magnetic stimulation (TMS) of the motor cortex and highlight the growing evidence for TMS in the diagnostic process. Finally, accurately monitoring disease progression is crucial for the successful implementation of clinical trials. Neurophysiological measures of disease state have been incorporated into clinical trials for over 20 years and we review prominent techniques for assessing disease progression.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Electromiografía
/
Estimulación Magnética Transcraneal
/
Esclerosis Amiotrófica Lateral
/
Neurofisiología
Límite:
Humans
Idioma:
En
Revista:
Int Rev Neurobiol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Australia