A Computational Framework for the Administration of 5-Aminovulinic Acid Before Glioblastoma Surgery.
Bull Math Biol
; 86(7): 83, 2024 Jun 06.
Article
en En
| MEDLINE
| ID: mdl-38842602
ABSTRACT
5-Aminolevulinic Acid (5-ALA) is the only fluorophore approved by the FDA as an intraoperative optical imaging agent for fluorescence-guided surgery in patients with glioblastoma. The dosing regimen is based on rodent tests where a maximum signal occurs around 6 h after drug administration. Here, we construct a computational framework to simulate the transport of 5-ALA through the stomach, blood, and brain, and the subsequent conversion to the fluorescent agent protoporphyrin IX at the tumor site. The framework combines compartmental models with spatially-resolved partial differential equations, enabling one to address questions regarding quantity and timing of 5-ALA administration before surgery. Numerical tests in two spatial dimensions indicate that, for tumors exceeding the detection threshold, the time to peak fluorescent concentration is 2-7 h, broadly consistent with the current surgical guidelines. Moreover, the framework enables one to examine the specific effects of tumor size and location on the required dose and timing of 5-ALA administration before glioblastoma surgery.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Protoporfirinas
/
Simulación por Computador
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Neoplasias Encefálicas
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Glioblastoma
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Cirugía Asistida por Computador
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Conceptos Matemáticos
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Ácido Aminolevulínico
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Modelos Biológicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bull Math Biol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos