The emerging role of ACOD1/itaconate pathway in atherosclerosis.

Xu, Jingjing; Xu, Suowen

Xu, Jingjing; Xu, Suowen.

Afiliación

Xu J; Department of Endocrinology, Institute of Endocrine and Metabolic Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230022, China.
Xu S; Department of Endocrinology, Institute of Endocrine and Metabolic Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230022, China. Electronic address: sxu1984@ustc.edu.cn.

Trends Mol Med ; 30(9): 797-799, 2024 Sep.

Article en En | MEDLINE | ID: mdl-38845325

ABSTRACT

ABSTRACT

As an endogenous immunometabolite, itaconate has excellent anti-inflammatory effects. However, it remains unknown whether itaconate protects against atherosclerosis. Two recent studies, by Song et al. and Cyr et al., revealed the emerging role of the aconitate decarboxylase 1/itaconate pathway in atherosclerosis.

Asunto(s)

Aterosclerosis; Carboxiliasas; Succinatos; Animales; Humanos; Aterosclerosis/metabolismo; Aterosclerosis/fisiopatología; Carboxiliasas/metabolismo; Transducción de Señal/fisiología; Succinatos/metabolismo

Palabras clave

aconitate decarboxylase 1; atherosclerosis; itaconate

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Succinatos / Carboxiliasas / Aterosclerosis Límite: Animals / Humans Idioma: En Revista: Trends Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: China

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