Implications of innate immune sexual dimorphism for MASLD pathogenesis and treatment.
Trends Pharmacol Sci
; 45(7): 614-627, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38853100
ABSTRACT
Growing evidence suggests that metabolic dysfunction-associated steatotic liver disease (MASLD) is significantly higher in men versus women. Increased prevalence is observed in postmenopausal women, suggesting that age and sex (hormones) influence MASLD development and progression. Molecular data further reveal that sex regulates the innate immune responses with an essential role in MASLD progression. To date, there has been limited focus on the role of innate immune sexual dimorphism in MASLD, and differences between men and women are not considered in the current drug discovery landscape. In this review, we summarize the sex disparities and innate immune sexual dimorphism in MASLD pathogenesis. We further highlight the importance of harnessing sexual dimorphism in identifying therapeutic targets, developing pharmacological therapies, and designing (pre-) clinical studies for the personalized treatment for MASLD.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Caracteres Sexuales
/
Inmunidad Innata
Límite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Trends Pharmacol Sci
Año:
2024
Tipo del documento:
Article
País de afiliación:
Países Bajos