Pink adipose tissue: A paradigm of adipose tissue plasticity.
Ann Endocrinol (Paris)
; 85(3): 248-251, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38871512
ABSTRACT
Adipose tissue is highly plastic, as illustrated mainly by the transdifferentiation of white adipocytes into beige adipocytes, depending on environmental conditions. However, during gestation and lactation in rodent, there is an amazing phenomenon of transformation of subcutaneous adipose tissue into mammary glandular tissue, known as pink adipose tissue, capable of synthesizing and secreting milk. Recent work using transgenic lineage-tracing experiments, mainly carried out in Saverio Cinti's team, has demonstrated very convincingly that this process does indeed correspond to a transdifferentiation of white adipocytes into mammary alveolar cells (pink adipocytes) during gestation and lactation. This phenomenon is reversible, since during the post-lactation phase, pink adipocytes revert to the white adipocyte phenotype. The molecular mechanisms underlying this reversible transdifferentiation remain poorly understood.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lactancia
/
Tejido Adiposo
Límite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Ann Endocrinol (Paris)
Año:
2024
Tipo del documento:
Article