Association of plasma lactoferrin levels with disease severity in glaucoma patients.
Front Med (Lausanne)
; 11: 1385358, 2024.
Article
en En
| MEDLINE
| ID: mdl-38873213
ABSTRACT
Objective:
To explore the relationship between plasma lactoferrin (Lf) and glaucoma, assessing the clinical utility of Lf in glaucoma.Methods:
A cross-sectional study involved 161 glaucoma patients and 115 healthy controls, with a follow-up of 14 subjects after approximately 2 years. Plasma Lf markers were quantified using ELISA, comparing levels between glaucoma patients and healthy controls, and analyzing plasma Lf across different glaucoma severity grades.Results:
Glaucoma patients had significantly elevated plasma Lf levels compared to healthy controls (p < 0.001). Higher plasma Lf levels correlated with more severe disease stages (HPA grades showed ρ = 0.435, p < 0.001; AGIS grades showed ρ = 0.436, p < 0.001) and reduced retinal nerve fiber layer (RNFL) thickness (RNFL thickness showed ρ = -0.204, p = 0.024). ROC curve analysis demonstrated the efficacy of glaucoma markers in differentiating early-stage from advanced glaucoma.Conclusion:
Plasma Lf levels are significantly associated with glaucoma severity and may be involved in the pathogenic progression of the disease.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Front Med (Lausanne)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China