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The roles of metal ions in gallstones formation.
Tong, Kuinan; Jing, Chao; Wang, Tingting; Liu, Kun; Guo, Wei; Zhang, Zhongtao.
Afiliación
  • Tong K; Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Jing C; Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Wang T; Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Liu K; Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Guo W; Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Electronic address: guowei@ccmu.edu.cn.
  • Zhang Z; Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Electronic address: zhangzht@ccmu.edu.cn.
Asian J Surg ; 2024 Jun 14.
Article en En | MEDLINE | ID: mdl-38879366
ABSTRACT
Gallstones (GSs) disease is a common disease worldwide. The mechanisms of their formation are diverse and complex and are related to cholesterol metabolism, gallbladder motility, biliary tract infection, the immune response, and ion metabolism. In recent years, with the application of inductively coupled plasma‒mass spectrometry and other methods, studies have suggested a correlation between the metabolism of metal ions and GSs formation. A literature search on gallstones and metal ions was instituted on PubMed and EMBASE. The specific topics of interest were etiology, formation mechanism, component Analysis and metabolism. References of papers were subsequently searched to obtain older literature. After reading and summarizing a large amount of literature, we found that calcium, iron, and copper can potentially promote the release of inflammatory factors and increase the level of reactive oxygen species, which is positively correlated with GSs formation. While magnesium and zinc, with their antioxidant effects, are negatively correlated with GSs formation. Metal ions are not only a component of GSs but are also important biological signals. Metal ion metabolism affects the formation of GSs and understanding its mechanism of action is of clinical significance for the prevention, diagnosis and treatment of GSs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Asian J Surg Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Asian J Surg Año: 2024 Tipo del documento: Article País de afiliación: China
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