Complement C4 allotype association with and serum C4 concentration in an autoimmune disease in the dog.
Clin Immunol Immunopathol
; 35(1): 85-91, 1985 Apr.
Article
en En
| MEDLINE
| ID: mdl-3888458
ABSTRACT
Serum C4 concentrations and C4 allotypes were determined wherever possible on eight dogs with an autoimmune disorder characterized by antinuclear antibody (ANA) positivity, pyrexia, and seronegative arthritis. Three of the six dogs tested serially showed hypocomplementemia at disease onset with return to normal concentrations with clinical remission following steroid therapy. All five dogs C4 allotyped were phenotypically identical. The phenotype (C4-4) was significantly increased in the diseased dogs. Thus C4 allotype may provide a marker for susceptibility to development of an autoimmune disorder in the dog. Serum C4 concentrations may help in disease diagnosis and monitoring the effectiveness of therapy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
/
Complemento C4
/
Enfermedades de los Perros
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Clin Immunol Immunopathol
Año:
1985
Tipo del documento:
Article