The appropriate sample-handling procedure for measuring the plasma ß-amyloid level using a fully automated immunoassay.
Sci Rep
; 14(1): 14266, 2024 06 20.
Article
en En
| MEDLINE
| ID: mdl-38902510
ABSTRACT
Plasma ß-amyloid (Aß) assays are a promising tool for Alzheimer's disease diagnosis in clinical practice. To obtain reliable results, establishing an appropriate sample-handling procedure for each analytical platform is warranted. This study proposes an appropriate sample-handling procedure using HISCL analyzer by elucidating the individual/combined effects of pre-analytical parameters on plasma Aß42/Aß40 levels. We investigated the effects of various pre-analytical parameters, including storage times for whole blood, plasma, and freezing conditions, on plasma Aß42/Aß40 levels, and confirmed if these values met the acceptable criteria. Plasma Aß42/Aß40 levels were acceptable in all conditions. We determined our protocol by confirming that plasma Aß42/Aß40 levels remained acceptable when combining pre-analytical parameters. We established an appropriate sample-handling protocol that ensures reliable measurement of plasma Aß42/Aß40 levels using HISCL analyzer. We believe the Aß assay, with our protocol, shows promise for aiding AD diagnosis in clinical settings.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos beta-Amiloides
/
Enfermedad de Alzheimer
Límite:
Aged
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Sci Rep
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón