Holo-transcobalamin is not associated with the risk of all-cause mortality in the general population.
Clin Nutr ESPEN
; 63: 53-56, 2024 Oct.
Article
en En
| MEDLINE
| ID: mdl-38909359
ABSTRACT
BACKGROUND & AIMS:
Holo-Transcobalamin (holo-TC) is the biologically active form of vitamin B12, a vitamin essential in human metabolism. The association between vitamin B12 (total cobalamin) and mortality risk has been controversially reported, whereas the relation between holo-TC and survival is unknown. In a population-based sample (n = 862, female share 42.8%, median age 62.3 years), we related serum holo-TC to the risk of all-cause mortality.METHODS:
We measured serum holo-TC by electro-chemiluminescence. Multivariable-adjusted Cox proportional hazards regression models were used to quantify the association between serum holo-TC and all-cause mortality.RESULTS:
Over a median follow-up time of 10.9 years, n = 99 individuals died. We did not find significant associations between serum holo-TC and the risk of all-cause mortality (HR 1.00 [95% CI 0.97-1.03] per 5-point increment in holo-TC), neither in the overall sample, nor in subgroups stratified by sex, diabetes, or hypertension.CONCLUSION:
The biologically active form of vitamin B12, holo-TC, is not related to the risk of all-cause mortality in a moderate-sized sample from the general population.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vitamina B 12
/
Transcobalaminas
/
Modelos de Riesgos Proporcionales
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Nutr ESPEN
/
Clinical nutrition ESPEN
Año:
2024
Tipo del documento:
Article