Cerebrospinal fluid distribution and pharmacokinetics of ponatinib in Ph1-positive acute lymphoblastic leukemia.

Walczak, Pierre; Fodil, Sofiane; Vignal, Nicolas; Cabannes-Hamy, Aurelie; Boissel, Nicolas; Raffoux, Emmanuel; Cayuela, Jean-Michel; Goldwirt, Lauriane; Lengliné, Etienne

Walczak, Pierre; Fodil, Sofiane; Vignal, Nicolas; Cabannes-Hamy, Aurelie; Boissel, Nicolas; Raffoux, Emmanuel; Cayuela, Jean-Michel; Goldwirt, Lauriane; Lengliné, Etienne.

Afiliación

Walczak P; Hôpital Saint-Louis, APHP, Paris, France.
Fodil S; Hopital Saint-Louis, Paris, France.
Vignal N; Saint-Louis Hospital, France.
Cabannes-Hamy A; Université de Paris Cité, France.
Boissel N; Hopital Saint-Louis, AP-HP, Paris, France.
Raffoux E; Hopital Saint Louis, PARIS, France.
Cayuela JM; Centre hospitalier de Versailles, France.
Goldwirt L; APHP, Hôpital Saint-Louis, Paris, France.
Lengliné E; Saint Louis hospital, Paris, France.

Blood ; 2024 Jun 25.

Article en En | MEDLINE | ID: mdl-38917352

ABSTRACT

ABSTRACT

Tyrosine kinase inhibitors have improved outcomes in Philadelphia-positive ALL, but their efficacy in CNS disease remains uncertain. Ponatinib was studied for CNS distribution in 22 samples from 16 patients. CSF concentrations fell below the 40nM threshold, suggesting suboptimal CNS exposure.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Blood Año: 2024 Tipo del documento: Article País de afiliación: Francia