Noncoding RNA-chromatin association: Functions and mechanisms.
Fundam Res
; 3(5): 665-675, 2023 Sep.
Article
en En
| MEDLINE
| ID: mdl-38933302
ABSTRACT
Pervasive transcription of the mammalian genome produces hundreds of thousands of noncoding RNAs (ncRNAs). Numerous studies have suggested that some of these ncRNAs regulate multiple cellular processes and play important roles in physiological and pathological processes. Notably, a large subset of ncRNAs is enriched on chromatin and participates in regulating gene expression and the dynamics of chromatin structure and status. In this review, we summarize recent advances in the functional study of chromatin-associated ncRNAs and mechanistic insights into how these ncRNAs associate with chromatin. We also discuss the potential future challenges which still need to be overcome in this field.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Fundam Res
Año:
2023
Tipo del documento:
Article
País de afiliación:
China