Synthesis, characterization and biological evaluation of aurones as potential neuroprotective agents.
Future Med Chem
; 16(16): 1649-1663, 2024 Aug 17.
Article
en En
| MEDLINE
| ID: mdl-38940451
ABSTRACT
Aim:
To synthesize aurone (Ar) derivatives and to demonstrate their effects against diabetes mellitus (DM) and neurodegeneration.Materials &methods:
Five Ar (A-E) derivatives were synthesized, characterized by proton NMR and screened for antioxidant, anti-diabetic and anti-cholinesterase activities. They were further evaluated for neuroprotective effects in streptozotocin (STZ)-induced neurodegenerative model.Results:
Among the aurone derivatives ArE demonstrated significant reversal of cognitive impairment, oxidative stress and neuroinflammation. Biochemical analysis revealed anti-diabetic and neuroprotective effects, possibly through downregulation of inflammatory markers and upregulation of antioxidant enzymes.Conclusion:
Synthesized Ar (A-E) exhibits promising therapeutic potential against STZ-induced neurodegeneration and DM by modulating inflammatory and oxidative pathways, suggesting a novel avenue for disease management.
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Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Benzofuranos
/
Fármacos Neuroprotectores
Límite:
Animals
Idioma:
En
Revista:
Future Med Chem
Año:
2024
Tipo del documento:
Article