Causal relationship between endometrial cancer and risk of breast cancer: A 2-sample Mendelian randomization study.
Medicine (Baltimore)
; 103(26): e38732, 2024 Jun 28.
Article
en En
| MEDLINE
| ID: mdl-38941373
ABSTRACT
Several studies have confirmed the important role of endometrial cancer (EC) in the development and progression of breast cancer (BC), and this study will explore the causal relationship between EC and BC by 2-sample Mendelian randomization analysis. Pooled data from published genome-wide association studies were used to assess the association between EC and BC risk in women using 5 methods, namely, inverse variance weighting (IVW), MR-Egger, weighted median (WME), simple multimaximetry (SM) and weighted multimaximetry (WM) with the EC-associated genetic loci as the instrumental variables (IV) and sensitivity analyses were used to assess the robustness of the results. The statistical results showed a causal association between EC and BC (IVW ORâ
=â
1.07, 95% CIâ
=â
1.01-1.32, Pâ
=â
.02; MR-Egger ORâ
=â
1.21, 95% CIâ
=â
0.71-1.51, Pâ
=â
.11; weighted median ORâ
=â
1.05, 95% CIâ
=â
0.97-1.31, Pâ
=â
.19; simple plurality method:
ORâ =â 0.98, 95% CIâ =â 0.81-1.15, Pâ =â .78; weighted pluralitymethod:
ORâ =â 0.98, 95% CIâ =â 0.81-1.14, Pâ =â .75), and the results of the sensitivity analyses showed that there was no significant heterogeneity or multiplicity, and the results were stable. EC is associated with an increased risk of developing BC. The results of this MR analysis can be used as a guideline for screening for BC in women with EC and to help raise awareness of screening for early detection and treatment.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Neoplasias Endometriales
/
Estudio de Asociación del Genoma Completo
/
Análisis de la Aleatorización Mendeliana
Límite:
Female
/
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China