Invasive and metastatic hydatidiform moles in Slovakia in 1993â2022.
Bratisl Lek Listy
; 125(7): 423-428, 2024.
Article
en En
| MEDLINE
| ID: mdl-38943503
ABSTRACT
OBJECTIVE:
A retrospective analysis of invasive and metastatic hydatidiform moles (HM) in the Slovak Republic (SR)âepidemiology, patient characteristics and treatment outcomes. BACKROUND Invasive and metastatic mole is a highly curable type of gestational trophoblastic neoplasia. Both invasive and metastatic HM may be cured by hysterectomy without adjuvant chemotherapy.METHODS:
Nineteen cases of histopathologically confirmed HM (10 invasive and 9 metastatic) were treated in SR from 1993 to 2022. Patients were divided into two groups according to treatment modality (hysterectomy only â 8; hysterectomy and chemotherapy â 11). The parameters included in the analysis were patient age, antecedent pregnancy, human chorionic gonadotropin level, tumor size and time to remission.RESULTS:
The incidence of invasive and metastatic HM in the SR was 1121,253 pregnancies, or 186,589 live births. The overall cure rate was 100%, without recurrence. Hysterectomy was performed as first-line therapy in 14 patients, with a cure rate of 57.1%. 4 out of 8 patients (50%) with metastatic moles, who underwent first-line hysterectomy, were cured without chemotherapy. There was no statistically significant difference between the two groups in all selected parameters.CONCLUSION:
First-line hysterectomy may lead to remission without adjuvant chemotherapy or reduce the number of chemotherapies in invasive and metastatic HM (Tab. 4, Fig. 2, Ref. 21).Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Uterinas
/
Histerectomía
Límite:
Adult
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Female
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Humans
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Middle aged
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Pregnancy
País/Región como asunto:
Europa
Idioma:
En
Revista:
Bratisl Lek Listy
Año:
2024
Tipo del documento:
Article