Plasma proteins and inflammatory dermatoses: proteome-wide Mendelian randomization and colocalization analyses.
Arch Dermatol Res
; 316(7): 443, 2024 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-38951247
ABSTRACT
Current genome-wide association studies (GWAS) of plasma proteomes provide additional possibilities for finding new drug targets for inflammatory dermatoses. We performed proteome-wide Mendelian randomization (MR) and colocalization analyses to identify novel potential drug targets for inflammatory dermatoses. We performed MR and colocalization analysis using genetic variation as instrumental variables to determine the causal relationship between circulating plasma proteins and inflammatory dermatoses. 5 plasma proteins were found to be causally associated with dermatitis eczematosa, SLE, urticaria and psoriasis using cis-pQTLs as instrumental variables, but not found in AD and LP. 19 candidate genes with high colocalization evidence were identified. These potential drug targets still require more research and rigorous validation in future trials.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Sanguíneas
/
Proteoma
/
Estudio de Asociación del Genoma Completo
/
Análisis de la Aleatorización Mendeliana
Límite:
Humans
Idioma:
En
Revista:
Arch Dermatol Res
Año:
2024
Tipo del documento:
Article
País de afiliación:
China