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Lymphoid organ-targeted nanomaterials for immunomodulation of cancer, inflammation, and beyond.
Hsu, Jessica C; Liu, Peng; Song, Yangmeihui; Song, Wenyu; Saladin, Rachel J; Peng, Ying; Hu, Shuo; Lan, Xiaoli; Cai, Weibo.
Afiliación
  • Hsu JC; Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA. wcai@uwhealth.org.
  • Liu P; Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA. wcai@uwhealth.org.
  • Song Y; Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.
  • Song W; Key Laboratory of Biological Nanotechnology of National Health Commission, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, P. R. China.
  • Saladin RJ; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430073, P. R. China.
  • Peng Y; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430073, P. R. China.
  • Hu S; Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan 430073, P. R. China.
  • Lan X; Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA. wcai@uwhealth.org.
  • Cai W; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430073, P. R. China.
Chem Soc Rev ; 53(15): 7657-7680, 2024 Jul 29.
Article en En | MEDLINE | ID: mdl-38958009
ABSTRACT
Nanomaterials exhibit significant potential for stimulating immune responses, offering both local and systemic modulation across a variety of diseases. The lymphoid organs, such as the spleen and lymph nodes, are home to various immune cells, including monocytes and dendritic cells, which contribute to both the progression and prevention/treatment of diseases. Consequently, many nanomaterial formulations are being rationally designed to target these organs and engage with specific cell types, thereby inducing therapeutic and protective effects. In this review, we explore crucial cellular interactions and processes involved in immune regulation and highlight innovative nano-based immunomodulatory approaches. We outline essential considerations in nanomaterial design with an emphasis on their impact on biological interactions, targeting capabilities, and treatment efficacy. Through selected examples, we illustrate the strategic targeting of therapeutically active nanomaterials to lymphoid organs and the subsequent immunomodulation for infection resistance, inflammation suppression, self-antigen tolerance, and cancer immunotherapy. Additionally, we address current challenges, discuss emerging topics, and share our outlook on future developments in the field.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanoestructuras / Inmunomodulación / Inflamación / Neoplasias Límite: Animals / Humans Idioma: En Revista: Chem Soc Rev Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanoestructuras / Inmunomodulación / Inflamación / Neoplasias Límite: Animals / Humans Idioma: En Revista: Chem Soc Rev Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
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