Inhibition of KIF20A enhances the immunotherapeutic effect of hepatocellular carcinoma by enhancing c-Myc ubiquitination.

Chen, Shujia; Zhao, Lili; Liu, Jie; Han, Ping; Jiang, Wentao; Liu, Yonggang; Hou, Jiancun; Wang, Fengmei; Li, Jia

Chen, Shujia; Zhao, Lili; Liu, Jie; Han, Ping; Jiang, Wentao; Liu, Yonggang; Hou, Jiancun; Wang, Fengmei; Li, Jia.

Afiliación

Chen S; Clinical School of the Second People's Hospital, Tianjin Medical University, Tianjin, 300211, China; Department of Hepatology, Tianjin Second People's Hospital, No. 7, Sudi South Road, Nankai District, Tianjin, 300192, China.
Zhao L; Department of Hepatology, Tianjin Second People's Hospital, No. 7, Sudi South Road, Nankai District, Tianjin, 300192, China.
Liu J; Department of Hepatology, Tianjin Second People's Hospital, No. 7, Sudi South Road, Nankai District, Tianjin, 300192, China.
Han P; Clinical School of the Second People's Hospital, Tianjin Medical University, Tianjin, 300211, China; Department of Hepatology, Tianjin Second People's Hospital, No. 7, Sudi South Road, Nankai District, Tianjin, 300192, China.
Jiang W; Department of Liver Transplantation, Tianjin First Center Hospital, 2 West Baoshan Road, Xiqing District, Tianjin, 300392, China.
Liu Y; Department of Pathology, Tianjin Second People's Hospital, No. 7, Sudi South Road, Nankai District, Tianjin, 300192, China.
Hou J; Department of Liver Surgery, Tianjin Second People's Hospital, No. 7, Sudi South Road, Nankai District, Tianjin, 300192, China.
Wang F; Department of Hepatology and Gastroenterology, Tianjin First Center Hospital, 2 West Baoshan Road, Xiqing District, Tianjin, 300392, China. Electronic address: wangfengmei@tmu.edu.cn.
Li J; Department of Hepatology, Tianjin Second People's Hospital, No. 7, Sudi South Road, Nankai District, Tianjin, 300192, China. Electronic address: JiaLi_0503@tmu.edu.cn.

Cancer Lett ; 598: 217105, 2024 Aug 28.

Article en En | MEDLINE | ID: mdl-38971490

Asunto(s)

Carcinoma Hepatocelular; Proteína 7 que Contiene Repeticiones F-Box-WD; Cinesinas; Neoplasias Hepáticas; Proteínas Proto-Oncogénicas c-myc; Ubiquitinación; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/inmunología; Carcinoma Hepatocelular/patología; Carcinoma Hepatocelular/tratamiento farmacológico; Carcinoma Hepatocelular/metabolismo; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/patología; Neoplasias Hepáticas/inmunología; Neoplasias Hepáticas/tratamiento farmacológico; Neoplasias Hepáticas/metabolismo; Animales; Humanos; Ratones; Cinesinas/genética; Cinesinas/antagonistas & inhibidores; Cinesinas/metabolismo; Proteínas Proto-Oncogénicas c-myc/genética; Proteínas Proto-Oncogénicas c-myc/metabolismo; Proteína 7 que Contiene Repeticiones F-Box-WD/genética; Proteína 7 que Contiene Repeticiones F-Box-WD/metabolismo; Inhibidores de Puntos de Control Inmunológico/farmacología; Inhibidores de Puntos de Control Inmunológico/uso terapéutico; Línea Celular Tumoral; Ratones Noqueados; Ensayos Antitumor por Modelo de Xenoinjerto; Proliferación Celular; Inmunoterapia/métodos; Masculino; Pronóstico; Regulación Neoplásica de la Expresión Génica

Palabras clave

FBXW7; Hepatocellular carcinoma; KIF20A; MMR; Metabolic reprogramming; PD-1; c-Myc

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas c-myc / Cinesinas / Carcinoma Hepatocelular / Ubiquitinación / Proteína 7 que Contiene Repeticiones F-Box-WD / Neoplasias Hepáticas Límite: Animals / Humans / Male Idioma: En Revista: Cancer Lett Año: 2024 Tipo del documento: Article País de afiliación: China

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