Intricacies of aging and Down syndrome.
Neurosci Biobehav Rev
; 164: 105794, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38971514
ABSTRACT
Down syndrome is the most frequently occurring genetic condition, with a substantial escalation in risk associated with advanced maternal age. The syndrome is characterized by a diverse range of phenotypes, affecting to some extent all levels of organization, and its progeroid nature - early manifestation of aspects of the senile phenotype. Despite extensive investigations, many aspects and mechanisms of the disease remain unexplored. The current review aims to provide an overview of the main causes and manifestations of Down syndrome, while also examining the phenomenon of accelerated aging and exploring potential therapeutic strategies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Síndrome de Down
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Neurosci Biobehav Rev
Año:
2024
Tipo del documento:
Article
País de afiliación:
Rusia