Physiology of Nerve Regeneration: Key Factors Affecting Clinical Outcomes.
Hand Clin
; 40(3): 337-345, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38972678
ABSTRACT
Functional recovery after peripheral nerve injuries is disappointing despite surgical advances in nerve repair. This review summarizes the relatively short window of opportunity for successful nerve regeneration due to the decline in the expression of growth-associated genes and in turn, the decline in regenerative capacity of the injured neurons and the support provided by the denervated Schwann cells, and the atrophy of denervated muscles. Brief, low-frequency electrical stimulation and post-injury exercise regimes ameliorate these deficits in animal models and patients, but the misdirection of regenerating nerve fibers compromises functional recovery and remains an important area of future research.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Traumatismos de los Nervios Periféricos
/
Regeneración Nerviosa
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Hand Clin
Asunto de la revista:
ORTOPEDIA
Año:
2024
Tipo del documento:
Article