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Metabolic Effects of Ketogenic Diets: Exploring Whole-Body Metabolism in Connection with Adipose Tissue and Other Metabolic Organs.
Ahmad, Yusra; Seo, Dong Soo; Jang, Younghoon.
Afiliación
  • Ahmad Y; Department of Biology and Chemistry, Changwon National University, Changwon 51140, Republic of Korea.
  • Seo DS; Department of Biology and Chemistry, Changwon National University, Changwon 51140, Republic of Korea.
  • Jang Y; Department of Biology and Chemistry, Changwon National University, Changwon 51140, Republic of Korea.
Int J Mol Sci ; 25(13)2024 Jun 27.
Article en En | MEDLINE | ID: mdl-39000187
ABSTRACT
The ketogenic diet (KD) is characterized by minimal carbohydrate, moderate protein, and high fat intake, leading to ketosis. It is recognized for its efficiency in weight loss, metabolic health improvement, and various therapeutic interventions. The KD enhances glucose and lipid metabolism, reducing triglycerides and total cholesterol while increasing high-density lipoprotein levels and alleviating dyslipidemia. It significantly influences adipose tissue hormones, key contributors to systemic metabolism. Brown adipose tissue, essential for thermogenesis and lipid combustion, encounters modified UCP1 levels due to dietary factors, including the KD. UCP1 generates heat by uncoupling electron transport during ATP synthesis. Browning of the white adipose tissue elevates UCP1 levels in both white and brown adipose tissues, a phenomenon encouraged by the KD. Ketone oxidation depletes intermediates in the Krebs cycle, requiring anaplerotic substances, including glucose, glycogen, or amino acids, for metabolic efficiency. Methylation is essential in adipogenesis and the body's dietary responses, with DNA methylation of several genes linked to weight loss and ketosis. The KD stimulates FGF21, influencing metabolic stability via the UCP1 pathways. The KD induces a reduction in muscle mass, potentially involving anti-lipolytic effects and attenuating proteolysis in skeletal muscles. Additionally, the KD contributes to neuroprotection, possesses anti-inflammatory properties, and alters epigenetics. This review encapsulates the metabolic effects and signaling induced by the KD in adipose tissue and major metabolic organs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dieta Cetogénica Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci / Int. j. mol. sci. (Online) / International journal of molecular sciences (Online) Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dieta Cetogénica Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci / Int. j. mol. sci. (Online) / International journal of molecular sciences (Online) Año: 2024 Tipo del documento: Article
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