Correlation between matrix metalloproteinase-2, matrix metalloproteinase-9, and tissue inhibitor of metalloproteinases-1 and white matter hyperintensities in patients with cerebral small vessel disease based on cranial magnetic resonance 3D imaging.
Magn Reson Imaging
; : 110213, 2024 Jul 23.
Article
en En
| MEDLINE
| ID: mdl-39053592
ABSTRACT
OBJECTIVE:
The objective of this study was to investigate the correlation between serum levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinases-1 (TIMP-1) levels and their ratios with the severity of white matter hyperintensities (WMHs) in patients with cerebral small vessel disease (CSVD).METHODS:
This cross-sectional study was done on a prospective cohort of patients with CSVD. Qualitative and quantitative analyses of WMHs were performed using Fazekas grading and lesion prediction algorithm (LPA) methods. Biomarkers MMP-2, MMP-9, and TIMP-1 were measured to explore their correlation with the severity of WMHs.RESULTS:
The sample consisted of 144 patients with CSVD. There were 63 male and 81 female patients, with an average age of 67.604⯱â¯8.727â¯years. Among these, 58.33% presented with white matter hyperintensities at Fazekas grading level 1, with an average total template volume of WMHs of 4.305â¯mL. MMP-2 (Pâ¯=â¯0.025), MMP-9 (Pâ¯=â¯0.008), TIMP-1 (Pâ¯=â¯0.026), and age (Pâ¯=â¯0.007) were identified as independent correlates of WMHs based on Fazekas grading. Independent correlates of the total template volume of WMHs included MMP-2 (Pâ¯=â¯0.023), TIMP-1 (Pâ¯=â¯0.046), age (Pâ¯=â¯0.047), systolic blood pressure (Pâ¯=â¯0.047), and homocysteine (Hcy) (Pâ¯=â¯0.014). In addition, age (Pâ¯=â¯0.003; Pâ¯<â¯0.001), interleukin-6 (IL-6) (Pâ¯<â¯0.001; Pâ¯=â¯0.044), Hcy (Pâ¯<â¯0.001; Pâ¯<â¯0.001), glycated hemoglobin (HbA1c) (Pâ¯=â¯0.016; Pâ¯=â¯0.043), and chronic kidney disease (Pâ¯<â¯0.001; Pâ¯<â¯0.001) were associated with both WMHs Fazekas grading and the total template volume of WMHs.CONCLUSION:
Serum levels of MMP-9, MMP-2, and TIMP-1 were independently associated with the Fazekas grading, while serum TIMP-1 and MMP-2 levels were independently related to the total template volume of WMHs. The association of TIMP-1 and MMP-2 with the severity of CSVD-related WMHs suggests their potential role as disease-related biomarkers. However, further research is required to uncover the specific mechanisms underlying these interactions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Magn Reson Imaging
Año:
2024
Tipo del documento:
Article
País de afiliación:
China