Metabolomic Applications in Gut Microbiota-Host Interactions in Human Diseases.
Gastroenterol Clin North Am
; 53(3): 383-397, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-39068001
ABSTRACT
The human gut microbiota, consisting of trillions of microorganisms, encodes diverse metabolic pathways that impact numerous aspects of host physiology. One key way in which gut bacteria interact with the host is through the production of small metabolites. Several of these microbiota-dependent metabolites, such as short-chain fatty acids, have been shown to modulate host diseases. In this review, we examine how disease-associated metabolic signatures are identified using metabolomic platforms, and where metabolomics is applied in gut microbiota-disease interactions. We further explore how integration of metagenomic and metabolomic data in human studies can facilitate biomarkers discoveries in precision medicine.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Metabolómica
/
Microbioma Gastrointestinal
Límite:
Humans
Idioma:
En
Revista:
Gastroenterol Clin North Am
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos