Buprenorphine/naloxone - one formulation that doesn't fit all: a case report.
Harm Reduct J
; 21(1): 143, 2024 Jul 30.
Article
en En
| MEDLINE
| ID: mdl-39080714
ABSTRACT
BACKGROUND:
Sublingual buprenorphine, approved for treatment of opioid use disorder since 2002, is most commonly available in co-formulation with naloxone. Naloxone is an opioid antagonist minimally absorbed when sublingual (SL) buprenorphine/naloxone is taken as prescribed; it is thought to reduce potential for misuse via intravenous administration. However, growing data and clinical experience demonstrate that previously accepted assumptions about the pharmacokinetics of these medications may not apply to all patients. CASE PRESENTATION We present a patient whose adverse post-administration side effects on SL buprenorphine/naloxone resolved with transition to SL buprenorphine monoproduct.DISCUSSION:
Naloxone can be detected in nearly all patients taking SL buprenorphine/naloxone, though with apparent variability in clinical effect. In a minority of patients, naloxone can contribute to adverse and potentially treatment-limiting side effects. Furthermore, the naloxone component is commonly misunderstood by patients and providers and can foster mistrust in the therapeutic relationship if providers are perceived to be withholding a more tolerable formulation. Prescribers should have a low threshold to offer buprenorphine alone when clinically appropriate.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Combinación Buprenorfina y Naloxona
/
Antagonistas de Narcóticos
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Trastornos Relacionados con Opioides
Límite:
Adult
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Female
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Humans
Idioma:
En
Revista:
Harm Reduct J
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos