Genome-Scale Analyses Reveal Roadblocks to Monkey Cloning.
Cell Reprogram
; 2024 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-39088354
ABSTRACT
Cloning by somatic cell nuclear transfer (SCNT) remained challenging for Rhesus monkeys, mostly due to its low efficiency and neonatal death. Genome-scale analyses revealed that monkey SCNT embryos displayed widespread DNA methylation and transcriptional alterations, thus including loss of genomic imprinting that correlated with placental dysfunction. The transfer of inner cell masses (ICM) from cloned blastocysts into ICM-depleted fertilized embryos rescued placental insufficiency and gave rise to a cloned Rhesus monkey that reached adulthood without noticeable abnormalities.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Cell Reprogram
Año:
2024
Tipo del documento:
Article
País de afiliación:
Brasil